NAD+ & Semax
An overview of the research-backed benefits of NAD+ supplementation and the Semax peptide, with links to reputable sources.
NAD+ (Nicotinamide Adenine Dinucleotide)
Key Research (2025): A clinical trial at Massachusetts General Hospital found that nicotinamide riboside (NR) at 2,000mg daily showed improvements in fatigue, sleep quality, mood, and executive function in long COVID patients over 24 weeks. A Nestlé Research-led trial demonstrated both NR and NMN effectively increase NAD+ levels within 14 days.
⚡ Cellular Energy Production
NAD+ is essential for mitochondrial function and ATP production. Boosting NAD+ levels supports energy metabolism at the cellular level, combating age-related fatigue.
Source: Atria Institute →🧬 DNA Repair & Longevity
NAD+ activates sirtuins (SIRT1-SIRT7), enzymes involved in DNA repair, gene expression, and cellular stress resistance. In Werner syndrome patients, NR supplementation led to ~140% increase in plasma NAD+ and improved arterial stiffness.
Source: PubMed Central →🧠 Cognitive & Neurological Health
NAD+ supports brain health through improved mitochondrial function in neurons. Research in ataxia-telangiectasia patients showed improved neuromotor function with NAD+ supplementation.
Source: PubMed Central →💤 Sleep & Mood
The MGH long COVID trial found participants on NR reported improvements in sleep quality and mood. NAD+ plays a role in circadian rhythm regulation through sirtuin-mediated pathways.
Source: ScienceDaily →🦠 Gut Health
Both NR and NMN promote beneficial gut bacteria by converting into nicotinic acid in the gut. A 2025 Nestlé-led clinical trial showed sustained increases in systemic NAD+ levels and improved microbial metabolism.
Source: Nutrition Insight →❤️ Cardiovascular Support
Animal research and early human studies suggest NAD+ precursors may improve insulin sensitivity and cardiovascular markers. Werner syndrome patients showed improved cardio-ankle vascular index scores.
Source: PubMed Central →Semax (Synthetic ACTH 4-10 Analog)
Key Research: Semax increases BDNF (Brain-Derived Neurotrophic Factor) expression, modulates dopamine and serotonin systems, and provides neuroprotection. In Alzheimer's mouse models (APP/PS1), intranasal Semax restored cognitive function and reduced amyloid plaques in the cortex and hippocampus. Used clinically in Russia for stroke recovery.
🎯 Focus & Attention
Semax enhances concentration, working memory, and processing speed via dopamine modulation in the prefrontal cortex and improved cerebral blood flow. Effects can be noticeable within hours to days.
Source: BHR Center →🧠 Memory & Learning
By upregulating BDNF, Semax supports synaptic plasticity, neuronal survival, and memory formation. Studies show improved performance in novel object recognition and spatial memory tests.
Source: PubMed →🛡️ Neuroprotection
Semax reduces oxidative stress, inflammation, and ischemic damage in brain tissue. It has been used clinically in Russia for stroke neuroprotection, promoting neuronal health and resilience against cognitive decline.
Source: PubMed Central →🔄 Neuroplasticity
Through BDNF and nerve growth factor upregulation, Semax promotes the brain's ability to form new neural connections. This underlies its benefits for learning, adaptation, and recovery from neurological injury.
Source: PubMed Central →😊 Mood & Motivation
Semax modulates both dopamine and serotonin systems, contributing to improved mood, motivation, and emotional balance — without the stimulant-like side effects associated with traditional cognitive enhancers.
Source: Tydes Research →🧪 Alzheimer's Research
In APP/PS1 Alzheimer's mouse models, intranasal Semax restored cognitive functions in behavioral tests and reduced amyloid inclusions in the cortex and hippocampus — suggesting potential therapeutic applications.
Source: PubMed Central (2025) →N-Acetyl Semax (NASA): A modified version of Semax with higher bioavailability and potentially stronger effects. The acetylated form may cross the blood-brain barrier more efficiently, though comparative human studies are limited.
Where to Purchase
Reputable vendors with third-party testing and certificates of analysis.